Details of the Target

General Information of Target

Target ID LDTP09778
Target Name SHC-transforming protein 3 (SHC3)
Gene Name SHC3
Gene ID 53358
Synonyms
NSHC; SHCC; SHC-transforming protein 3; Neuronal Shc; N-Shc; Protein Rai; SHC-transforming protein C; Src homology 2 domain-containing-transforming protein C3; SH2 domain protein C3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAIKAVNSKAEVARARAALAVNICAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDG
NVLLDEMQIQHPTASLIAKVATAQDDVTGDGTTSNVLIIGELLKQADLYISEGLHPRIIA
EGFEAAKIKALEVLEEVKVTKEMKRKILLDVARTSLQTKVHAELADVLTEVVVDSVLAVR
RPGYPIDLFMVEIMEMKHKLGTDTKLIQGLVLDHGARHPDMKKRVEDAFILICNVSLEYE
KTEVNSGFFYKTAEEKEKLVKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPF
SLDSLAKHGIVALRRAKRRNMERLSLACGGMAVNSFEDLTVDCLGHAGLVYEYTLGEEKF
TFIEECVNPCSVTLLVKGPNKHTLTQVKDAIRDGLRAIKNAIEDGCMVPGAGAIEVAMAE
ALVTYKNSIKGRARLGVQAFADALLIIPKVLAQNAGYDPQETLVKVQAEHVESKQLVGVD
LNTGEPMVAADAGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLK
Target Bioclass
Other
Function
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Uniprot ID
Q92529
Ensemble ID
ENST00000375835.9
HGNC ID
HGNC:18181

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.I297L .
COLO679 SNV: p.G411E .
FADU SNV: p.D392N .
HKGZCC SNV: p.I282V .
HS936T SNV: p.G581E .
KATOIII SNV: p.A256T .
KPL1 SNV: p.M1? .
MCF7 SNV: p.M1? .
MEC1 SNV: p.F372S .
MONOMAC6 Insertion: p.N568_H569insRHLIN .
NCIH23 SNV: p.A434S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C477(1.34)  LDD2469  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 MGG123 C477(1.34)  LDD2469  [1]
 LDCM0023  KB03 MGG123 C477(1.29)  LDD2886  [1]
 LDCM0024  KB05 MGG123 C477(1.51)  LDD3303  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840