Details of the Target

General Information of Target

Target ID LDTP09776
Target Name Carnitine O-palmitoyltransferase 1, muscle isoform (CPT1B)
Gene Name CPT1B
Gene ID 1375
Synonyms
KIAA1670; Carnitine O-palmitoyltransferase 1, muscle isoform; CPT1-M; EC 2.3.1.21; Carnitine O-palmitoyltransferase I, muscle isoform; CPT I; CPTI-M; Carnitine palmitoyltransferase 1B; Carnitine palmitoyltransferase I-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVELEEALPVTTAEGMAKKVTKAGGSAALSPSKKRKNSKKKNQPGKYSQLVVETIRRLG
ERNGSSLAKIYTEAKKVPWFDQQNGRTYLKYSIKALVQNDTLLQVKGTGANGSFKLNRKK
LEGGGERRGAPAAATAPAPTAHKAKKAAPGAAGSRRADKKPARGQKPEQRSHKKGAGAKK
DKGGKAKKTAAAGGKKVKKAAKPSVPKVPKGRK
Target Type
Successful
Target Bioclass
Enzyme
Family
Carnitine/choline acetyltransferase family
Subcellular location
Mitochondrion outer membrane
Function
Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion.
TTD ID
T75888
Uniprot ID
Q92523
DrugMap ID
TTDL0NY
Ensemble ID
ENST00000312108.12
HGNC ID
HGNC:2329
ChEMBL ID
CHEMBL2216739

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1143 SNV: p.N266I .
HCT15 SNV: p.D631Y DBIA    Probe Info 
KO52 SNV: p.L43V .
MDAMB231 SNV: p.F712S .
MOLT4 SNV: p.L51I; p.H142Y .
NALM6 SNV: p.Y201N DBIA    Probe Info 
OVK18 SNV: p.A474V DBIA    Probe Info 
WM115 SNV: p.E410K .
WM2664 SNV: p.E410K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C586(1.71)  LDD3310  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 42-MG-BA C586(3.73)  LDD2244  [1]
 LDCM0023  KB03 42-MG-BA C586(2.26)  LDD2661  [1]
 LDCM0024  KB05 COLO792 C586(1.71)  LDD3310  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840