Details of the Target
General Information of Target
| Target ID | LDTP09774 | |||||
|---|---|---|---|---|---|---|
| Target Name | GPI mannosyltransferase 3 (PIGB) | |||||
| Gene Name | PIGB | |||||
| Gene ID | 9488 | |||||
| Synonyms |
GPI mannosyltransferase 3; EC 2.4.1.-; GPI mannosyltransferase III; GPI-MT-III; Phosphatidylinositol-glycan biosynthesis class B protein; PIG-B |
|||||
| 3D Structure | ||||||
| Sequence |
MRVAGAAKLVVAVAVFLLTFYVISQVFEIKMDASLGNLFARSALDTAARSTKPPRYKCGI
SKACPEKHFAFKMASGAANVVGPKICLEDNVLMSGVKNNVGRGINVALANGKTGEVLDTK YFDMWGGDVAPFIEFLKAIQDGTIVLMGTYDDGATKLNDEARRLIADLGSTSITNLGFRD NWVFCGGKGIKTKSPFEQHIKNNKDTNKYEGWPEVVEMEGCIPQKQD |
|||||
| Target Bioclass |
Enzyme
|
|||||
| Family |
Glycosyltransferase 22 family, PIGB subfamily
|
|||||
| Subcellular location |
Endoplasmic reticulum membrane
|
|||||
| Function | Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C248(6.66) | LDD3332 | [1] | |
|
IPM Probe Info |
 |
C248(0.75) | LDD1702 | [2] | |
|
TFBX Probe Info |
 |
N.A. | LDD0027 | [3] | |
Competitor(s) Related to This Target
References