Details of the Target

General Information of Target

Target ID LDTP09761
Target Name Transcription factor AP-2-beta (TFAP2B)
Gene Name TFAP2B
Gene ID 7021
Synonyms
Transcription factor AP-2-beta; AP2-beta; Activating enhancer-binding protein 2-beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPKKRPETQKTSEIVLRPRNKRSRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGP
QILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWH
PTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGT
TRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRM
HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG
ARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPN
FKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQ
EEARTRK
Target Bioclass
Transcription factor
Family
AP-2 family
Subcellular location
Nucleus
Function
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
Uniprot ID
Q92481
Ensemble ID
ENST00000393655.4
HGNC ID
HGNC:11743

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.R282DfsTer7 .
CORL88 SNV: p.D28E .
DAOY SNV: p.M176L .
HCC15 SNV: p.Q100Ter .
HEC1 SNV: p.T402M .
HS839T SNV: p.R287S .
HT115 SNV: p.P34L .
IM95 Deletion: p.P260LfsTer29 .
KMCH1 SNV: p.R321G .
MEWO SNV: p.P50T .
NCIH358 SNV: p.S37R .
PF382 SNV: p.T402M .
RH30 SNV: p.R300H .
SHP77 SNV: p.D31Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C87(2.18)  LDD3493  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AU565 C87(1.72)  LDD2265  [1]
 LDCM0023  KB03 AU565 C87(2.71)  LDD2682  [1]
 LDCM0024  KB05 ZR-75-1 C87(2.18)  LDD3493  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840