Details of the Target
General Information of Target
| Target ID | LDTP09741 | |||||
|---|---|---|---|---|---|---|
| Target Name | Ras and Rab interactor 2 (RIN2) | |||||
| Gene Name | RIN2 | |||||
| Gene ID | 54453 | |||||
| Synonyms |
RASSF4; Ras and Rab interactor 2; Ras association domain family 4; Ras inhibitor JC265; Ras interaction/interference protein 2 |
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| 3D Structure | ||||||
| Sequence |
MTAWTMGARGLDKRGSFFKLIDTIASEIGELKQEMVRTDVNLENGLEPAETHSMVRHKDG
GYSEEEDVKTCARDSGYDSLSNRLSILDRLLHTHPIWLQLSLSEEEAAEVLQAQPPGIFL VHKSTKMQKKVLSLRLPCEFGAPLKEFAIKESTYTFSLEGSGISFADLFRLIAFYCISRD VLPFTLKLPYAISTAKSEAQLEELAQMGLNFWSSPADSKPPNLPPPHRPLSSDGVCPASL RQLCLINGVHSIKTRTPSELECSQTNGALCFINPLFLKVHSQDLSGGLKRPSTRTPNANG TERTRSPPPRPPPPAINSLHTSPRLARTETQTSMPETVNHNKHGNVALPGTKPTPIPPPR LKKQASFLEAEGGAKTLSGGRPGAGPELELGTAGSPGGAPPEAAPGDCTRAPPPSSESRP PCHGGRQRLSDMSISTSSSDSLEFDRSMPLFGYEADTNSSLEDYEGESDQETMAPPIKSK KKRSSSFVLPKLVKSQLQKVSGVFSSFMTPEKRMVRRIAELSRDKCTYFGCLVQDYVSFL QENKECHVSSTDMLQTIRQFMTQVKNYLSQSSELDPPIESLIPEDQIDVVLEKAMHKCIL KPLKGHVEAMLKDFHMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMT MQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEY MMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSETRDTLRQWHKRRTTNRT IPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFV DETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS |
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| Target Bioclass |
Other
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| Family |
RIN (Ras interaction/interference) family
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| Subcellular location |
Cytoplasm
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| Function |
Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| CFPAC1 | SNV: p.R676W | . | |||
| FUOV1 | SNV: p.K749N | . | |||
| HEC1B | SNV: p.F156L | . | |||
| HT | SNV: p.P382S | . | |||
| IGROV1 | SNV: p.Q788Ter | DBIA Probe Info | |||
| JURKAT | Deletion: p.I477SfsTer24 | . | |||
| KASUMI2 | SNV: p.P644L | . | |||
| KYSE30 | SNV: p.K827Q | . | |||
| LNCaP clone FGC | SNV: p.A794T | . | |||
| MM1S | SNV: p.V818M | . | |||
| NCIH1155 | SNV: p.M595I | DBIA Probe Info | |||
| NCIH2172 | SNV: p.G640W | DBIA Probe Info | |||
| PF382 | SNV: p.M610T | . | |||
| SW1990 | SNV: p.P421R | DBIA Probe Info | |||
| VCAP | SNV: p.L724F | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
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C187(2.05) | LDD3319 | [1] | |
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NAIA_4 Probe Info |
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C262(0.00); C408(0.00); C802(0.00) | LDD2226 | [2] | |
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WYneN Probe Info |
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C138(0.00); C802(0.00) | LDD0021 | [3] | |
|
IPM Probe Info |
 |
C138(0.00); C422(0.00) | LDD2156 | [4] | |
Competitor(s) Related to This Target
References