Details of the Target

General Information of Target

Target ID LDTP09738
Target Name Jun dimerization protein 2 (JDP2)
Gene Name JDP2
Gene ID 122953
Synonyms
Jun dimerization protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMPGQIPDPSVTTGSLPGLGPLTGLPSSALTVEELKYADIRNLGAMIAPLHFLEVKLGKR
PQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEE
LKQERQQLILMLNRHRPTCIVRTDSVKTPESEGNPLLEQLEKK
Target Bioclass
Transcription factor
Family
BZIP family, ATF subfamily
Subcellular location
Nucleus
Function
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.
Uniprot ID
Q8WYK2
Ensemble ID
ENST00000267569.5
HGNC ID
HGNC:17546

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGR37 Substitution: p.T13A .
IGR39 Substitution: p.T13A .
NOMO1 SNV: p.R142Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		N.A.  LDD0246  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon regulatory factor 2-binding protein 1 (IRF2BP1) IRF2BP family Q8IU81
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) BZIP family P18848
DNA damage-inducible transcript 3 protein (DDIT3) BZIP family P35638
Transcription factor JunB (JUNB) BZIP family P17275

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pseudoephedrine Small molecular drug DB00852

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.