Details of the Target

General Information of Target

Target ID LDTP09735
Target Name Inhibitor of growth protein 5 (ING5)
Gene Name ING5
Gene ID 84289
Synonyms
Inhibitor of growth protein 5; p28ING5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATAMYLEHYLDSIENLPCELQRNFQLMRELDQRTEDKKAEIDILAAEYISTVKTLSPDQ
RVERLQKIQNAYSKCKEYSDDKVQLAMQTYEMVDKHIRRLDADLARFEADLKDKMEGSDF
ESSGGRGLKKGRGQKEKRGSRGRGRRTSEEDTPKKKKHKGGSEFTDTILSVHPSDVLDMP
VDPNEPTYCLCHQVSYGEMIGCDNPDCPIEWFHFACVDLTTKPKGKWFCPRCVQEKRKKK
Target Bioclass
Other
Family
ING family
Subcellular location
Nucleus
Function
Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner.
Uniprot ID
Q8WYH8
Ensemble ID
ENST00000313552.11
HGNC ID
HGNC:19421

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0162  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase Jade-2 (JADE2) JADE family Q9NQC1
Neuron navigator 2 (NAV2) Nav/unc-53 family Q8IVL1
Probable E3 ubiquitin-protein ligase TRIML2 (TRIML2) . Q8N7C3
Sulfite oxidase, mitochondrial (SUOX) . P51687
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
mRNA export factor GLE1 (GLE1) GLE1 family Q53GS7
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
THAP domain-containing protein 6 (THAP6) . Q8TBB0
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BEX3 (BEX3) BEX family Q00994
Deuterosome assembly protein 1 (DEUP1) CEP63 family Q05D60
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
KxDL motif-containing protein 1 (KXD1) KXD1 family Q9BQD3
Actin-binding protein WASF1 (WASF1) SCAR/WAVE family Q92558
Arfaptin-2 (ARFIP2) . P53365
Cell division cycle-associated 7-like protein (CDCA7L) . Q96GN5
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Islet cell autoantigen 1 (ICA1) . Q05084
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Uncharacterized protein C3orf62 (C3orf62) . Q6ZUJ4

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264