Details of the Target

General Information of Target

Target ID LDTP09726
Target Name Nanos homolog 1 (NANOS1)
Gene Name NANOS1
Gene ID 340719
Synonyms
NOS1; Nanos homolog 1; NOS-1; EC_Rep1a
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAFPWAPRSPRRGRAPPPMALVPSARYVSAPGPAHPQPFSSWNDYLGLATLITKAVDGE
PRFGCARGGNGGGGSPPSSSSSSCCSPHTGAGPGALGPALGPPDYDEDDDDDSDEPGSRG
RYLGSALELRALELCAGPAEAGLLEERFAELSPFAGRAAAVLLGCAPAAAAAATTTSEAT
PREERAPAWAAEPRLHAASGAAAARLLKPELQVCVFCRNNKEAMALYTTHILKGPDGRVL
CPVLRRYTCPLCGASGDNAHTIKYCPLSKVPPPPARPPPRSARDGPPGKKLR
Target Bioclass
Other
Family
Nanos family
Subcellular location
Cytoplasm, perinuclear region
Function
May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.
Uniprot ID
Q8WY41
Ensemble ID
ENST00000425699.3
HGNC ID
HGNC:23044

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C241(2.09)  LDD3493  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AU565 C241(2.04)  LDD2265  [1]
 LDCM0023  KB03 AU565 C241(3.15)  LDD2682  [1]
 LDCM0024  KB05 ZR-75-1 C241(2.09)  LDD3493  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840