General Information of Target

Target ID LDTP09658
Target Name Interactor protein for cytohesin exchange factors 1 (IPCEF1)
Gene Name IPCEF1
Gene ID 26034
Synonyms
KIAA0403; Interactor protein for cytohesin exchange factors 1; Phosphoinositide-binding protein PIP3-E
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSYMAIDGSALVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSN
KWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYF
AAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTA
QQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITF
AVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIM
DKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIR
TLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDDT
PQELKKSPSSPSVENSI
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner.
Uniprot ID
Q8WWN9
Ensemble ID
ENST00000265198.8
HGNC ID
HGNC:21204

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C191(4.60)  LDD3388  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 786-O C22(1.57)  LDD2247  [1]
 LDCM0023  KB03 786-O C22(1.98)  LDD2664  [1]
 LDCM0024  KB05 OVTOKO C191(4.60)  LDD3388  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840