Details of the Target
General Information of Target
| Target ID | LDTP09643 | |||||
|---|---|---|---|---|---|---|
| Target Name | Glycosylated lysosomal membrane protein (GLMP) | |||||
| Gene Name | GLMP | |||||
| Gene ID | 112770 | |||||
| Synonyms |
C1orf85; Glycosylated lysosomal membrane protein; Lysosomal protein NCU-G1 |
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| 3D Structure | ||||||
| Sequence |
MRGSVECTWGWGHCAPSPLLLWTLLLFAAPFGLLGEKTRQVSLEVIPNWLGPLQNLLHIR
AVGTNSTLHYVWSSLGPLAVVMVATNTPHSTLSVNWSLLLSPEPDGGLMVLPKDSIQFSS ALVFTRLLEFDSTNVSDTAAKPLGRPYPPYSLADFSWNNITDSLDPATLSATFQGHPMND PTRTFANGSLAFRVQAFSRSSRPAQPPRLLHTADTCQLEVALIGASPRGNRSLFGLEVAT LGQGPDCPSMQEQHSIDDEYAPAVFQLDQLLWGSLPSGFAQWRPVAYSQKPGGRESALPC QASPLHPALAYSLPQSPIVRAFFGSQNNFCAFNLTFGASTGPGYWDQHYLSWSMLLGVGF PPVDGLSPLVLGIMAVALGAPGLMLLGGGLVLLLHHKKYSEYQSIN |
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| Target Bioclass |
Transporter and channel
|
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| Family |
GLMP family
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| Subcellular location |
Lysosome membrane
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| Function | Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C216(1.71) | LDD3427 | [1] | |
|
5E-2FA Probe Info |
 |
N.A. | LDD2235 | [2] | |
|
m-APA Probe Info |
 |
N.A. | LDD2231 | [2] | |
|
IA-alkyne Probe Info |
 |
N.A. | LDD0162 | [3] | |
Competitor(s) Related to This Target
References