Details of the Target

General Information of Target

Target ID LDTP09638
Target Name Zinc finger protein ZFPM2 (ZFPM2)
Gene Name ZFPM2
Gene ID 23414
Synonyms
FOG2; ZNF89B; Zinc finger protein ZFPM2; Friend of GATA protein 2; FOG-2; Friend of GATA 2; hFOG-2; Zinc finger protein 89B; Zinc finger protein multitype 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRRKQSKPRQIKRPLEDAIEDEEEECPSEETDIISKGDFPLEESFSTEFGPENLSCEEV
EYFCNKGDDEGIQETAESDGDTQSEKPGQPGVETDDWDGPGELEVFQKDGERKIQSRQQL
PVGTTWGPFPGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDNKNNCIVYSKGGQ
LWCTTTKAISEGEELIAFVVDFDSRLQAASQMTLTEGMYPARLLDSIQLLPQQAAMASIL
PTAIVNKDIFPCKSCGIWYRSERNLQAHLMYYCSGRQREAAPVSEENEDSAHQISSLCPF
PQCTKSFSNARALEMHLNSHSGVKMEEFLPPGASLKCTVCSYTADSVINFHQHLFSHLTQ
AAFRCNHCHFGFQTQRELLQHQELHVPSGKLPRESDMEHSPSATEDSLQPATDLLTRSEL
PQSQKAMQTKDASSDTELDKCEKKTQLFLTNQRPEIQPTTNKQSFSYTKIKSEPSSPRLA
SSPVQPNIGPSFPVGPFLSQFSFPQDITMVPQASEILAKMSELVHRRLRHGSSSYPPVIY
SPLMPKGATCFECNITFNNLDNYLVHKKHYCSSRWQQMAKSPEFPSVSEKMPEALSPNTG
QTSINLLNPAAHSADPENPLLQTSCINSSTVLDLIGPNGKGHDKDFSTQTKKLSTSSNND
DKINGKPVDVKNPSVPLVDGESDPNKTTCEACNITFSRHETYMVHKQYYCATRHDPPLKR
SASNKVPAMQRTMRTRKRRKMYEMCLPEQEQRPPLVQQRFLDVANLNNPCTSTQEPTEGL
GECYHPRCDIFPGIVSKHLETSLTINKCVPVSKCDTTHSSVSCLEMDVPIDLSKKCLSQS
ERTTTSPKRLLDYHECTVCKISFNKVENYLAHKQNFCPVTAHQRNDLGQLDGKVFPNPES
ERNSPDVSYERSIIKCEKNGNLKQPSPNGNLFSSHLATLQGLKVFSEAAQLIATKEENRH
LFLPQCLYPGAIKKAKGADQLSPYYGIKPSDYISGSLVIHNTDIEQSRNAENESPKGQAS
SNGCAALKKDSLPLLPKNRGMVIVNGGLKQDERPAANPQQENISQNPQHEDDHKSPSWIS
ENPLAANENVSPGIPSAEEQLSSIAKGVNGSSQAPTSGKYCRLCDIQFNNLSNFITHKKF
YCSSHAAEHVK
Target Bioclass
Transcription factor
Family
FOG (Friend of GATA) family
Subcellular location
Nucleus
Function
Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2.
Uniprot ID
Q8WW38
Ensemble ID
ENST00000407775.7
HGNC ID
HGNC:16700

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.P387S .
A549 SNV: p.E825Ter .
CAL27 SNV: p.Q452H .
COLO792 SNV: p.P673S .
COLO800 SNV: p.D789N .
HCC15 SNV: p.S657R .
HCT116 SNV: p.R734H .
HCT15 SNV: p.P673H; p.E1011D .
HT115 SNV: p.V245G; p.V386A .
JM1 SNV: p.I196S .
LNCaP clone FGC SNV: p.G1017V .
LS180 SNV: p.R713H .
MCF7 SNV: p.E800Q .
MDAMB468 SNV: p.M741I .
MELJUSO SNV: p.E31K .
MEWO SNV: p.G127E .
MOLT4 SNV: p.A243S .
NCIH1993 SNV: p.W162L .
NCIH2172 SNV: p.D22Y; p.G67C; p.P387H .
NCIH2286 SNV: p.G1093V .
NCIH23 SNV: p.V858L .
NCIN87 SNV: p.N868T .
OAW42 SNV: p.E748Q .
PF382 SNV: p.E288K; p.S603T .
RBE SNV: p.R527Ter .
TFK1 SNV: p.S407R .
UACC62 SNV: p.G1040E .
VMRCRCW SNV: p.P1058L .
WM2664 Insertion: p.T185NfsTer7 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD2156  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Prelamin-A/C (LMNA) Intermediate filament family P02545
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) . O43395

References

1 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019