Details of the Target

General Information of Target

Target ID LDTP09634
Target Name DnaJ homolog subfamily A member 4 (DNAJA4)
Gene Name DNAJA4
Gene ID 55466
Synonyms
DnaJ homolog subfamily A member 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEGEKFKLISQAYEVLSDPKK
RDVYDQGGEQAIKEGGSGSPSFSSPMDIFDMFFGGGGRMARERRGKNVVHQLSVTLEDLY
NGVTKKLALQKNVICEKCEGVGGKKGSVEKCPLCKGRGMQIHIQQIGPGMVQQIQTVCIE
CKGQGERINPKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEPGDV
IIVLDQKDHSVFQRRGHDLIMKMKIQLSEALCGFKKTIKTLDNRILVITSKAGEVIKHGD
LRCVRDEGMPIYKAPLEKGILIIQFLVIFPEKHWLSLEKLPQLEALLPPRQKVRITDDMD
QVELKEFCPNEQNWRQHREAYEEDEDGPQAGVQCQTA
Target Bioclass
Other
Subcellular location
Membrane
Uniprot ID
Q8WW22
Ensemble ID
ENST00000343789.7
HGNC ID
HGNC:14885

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JURKAT SNV: p.G299R .
OVK18 SNV: p.E41K .
TOV21G SNV: p.R27L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C164(1.21)  LDD3338  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A431 C301(2.01); C164(1.09)  LDD2258  [1]
 LDCM0023  KB03 A2058 C167(1.37)  LDD2670  [1]
 LDCM0024  KB05 MV4-11 C164(1.21)  LDD3338  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264