Details of the Target

General Information of Target

Target ID LDTP09625
Target Name Butyrophilin subfamily 2 member A2 (BTN2A2)
Gene Name BTN2A2
Gene ID 10385
Synonyms
BT2.2; BTF2; Butyrophilin subfamily 2 member A2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPAAALHFSLPASLLLLLLLLLLSLCALVSAQFTVVGPANPILAMVGENTTLRCHLSPE
KNAEDMEVRWFRSQFSPAVFVYKGGRERTEEQMEEYRGRITFVSKDINRGSVALVIHNVT
AQENGIYRCYFQEGRSYDEAILRLVVAGLGSKPLIEIKAQEDGSIWLECISGGWYPEPLT
VWRDPYGEVVPALKEVSIADADGLFMVTTAVIIRDKYVRNVSCSVNNTLLGQEKETVIFI
PESFMPSASPWMVALAVILTASPWMVSMTVILAVFIIFMAVSICCIKKLQREKKILSGEK
KVEQEEKEIAQQLQEELRWRRTFLHAADVVLDPDTAHPELFLSEDRRSVRRGPYRQRVPD
NPERFDSQPCVLGWESFASGKHYWEVEVENVMVWTVGVCRHSVERKGEVLLIPQNGFWTL
EMFGNQYRALSSPERILPLKESLCRVGVFLDYEAGDVSFYNMRDRSHIYTCPRSAFTVPV
RPFFRLGSDDSPIFICPALTGASGVMVPEEGLKLHRVGTHQSL
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, BTN/MOG family
Subcellular location
Membrane
Function Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.
Uniprot ID
Q8WVV5
Ensemble ID
ENST00000352867.6
HGNC ID
HGNC:1137

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.G504V .
AU565 SNV: p.T180A .
CAMA1 SNV: p.E434D .
KYSE30 Deletion: p.W70CfsTer25 .
RPMI8226 SNV: p.F239I .
TE10 SNV: p.L44V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C475(2.62)  LDD3310  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2058 C475(3.49)  LDD2253  [1]
 LDCM0023  KB03 A2058 C475(4.17)  LDD2670  [1]
 LDCM0024  KB05 COLO792 C475(2.62)  LDD3310  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264