Details of the Target

General Information of Target

Target ID LDTP09618
Target Name Tumor necrosis factor alpha-induced protein 8-like protein 1 (TNFAIP8L1)
Gene Name TNFAIP8L1
Gene ID 126282
Synonyms
Tumor necrosis factor alpha-induced protein 8-like protein 1; TIPE1; TNF alpha-induced protein 8-like protein 1; TNFAIP8-like protein 1; Oxidative stress-regulated gene-beta; Oxy-beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKML
KNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGL
LECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRM
LDEGSL
Target Bioclass
Other
Family
TNFAIP8 family
Subcellular location
Cytoplasm
Function Acts as a negative regulator of mTOR activity.
Uniprot ID
Q8WVP5
Ensemble ID
ENST00000327473.9
HGNC ID
HGNC:28279

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0174  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caveolae-associated protein 1 (CAVIN1) CAVIN family Q6NZI2
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6
Proteasome activator complex subunit 3 (PSME3) PA28 family P61289
U1 small nuclear ribonucleoprotein A (SNRPA) RRM U1 A/B'' family P09012
Tumor necrosis factor alpha-induced protein 8-like protein 1 (TNFAIP8L1) TNFAIP8 family Q8WVP5
Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) Universal ribosomal protein uL6 family P32969
Ecotropic viral integration site 5 protein homolog (EVI5) . O60447
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
SH3 and cysteine-rich domain-containing protein 3 (STAC3) . Q96MF2
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (ZRSR2) . Q15696

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060