Details of the Target
General Information of Target
| Target ID | LDTP09558 | |||||
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| Target Name | Marginal zone B- and B1-cell-specific protein (MZB1) | |||||
| Gene Name | MZB1 | |||||
| Gene ID | 51237 | |||||
| Synonyms |
MEDA7; PACAP; Marginal zone B- and B1-cell-specific protein; Mesenteric estrogen-dependent adipose 7; MEDA-7; Plasma cell-induced resident endoplasmic reticulum protein; Plasma cell-induced resident ER protein; pERp1; Proapoptotic caspase adapter protein
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| 3D Structure | ||||||
| Sequence |
MRLSLPLLLLLLGAWAIPGGLGDRAPLTATAPQLDDEEMYSAHMPAHLRCDACRAVAYQM
WQNLAKAETKLHTSNSGGRRELSELVYTDVLDRSCSRNWQDYGVREVDQVKRLTGPGLSE GPEPSISVMVTGGPWPTRLSRTCLHYLGEFGEDQIYEAHQQGRGALEALLCGGPQGACSE KVSATREEL |
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| Target Bioclass |
Other
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| Family |
MZB1 family
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| Subcellular location |
Cytoplasm; Endoplasmic reticulum lumen
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| Function |
Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.; Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
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Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C51(1.07) | LDD3431 | [1] | |
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4-Iodoacetamidophenylacetylene Probe Info |
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N.A. | LDD0038 | [2] | |
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IA-alkyne Probe Info |
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N.A. | LDD0166 | [3] | |
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Lodoacetamide azide Probe Info |
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N.A. | LDD0037 | [2] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References