Details of the Target

General Information of Target

Target ID LDTP09551
Target Name Cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1)
Gene Name CASTOR1
Gene ID 652968
Synonyms
GATSL3; Cytosolic arginine sensor for mTORC1 subunit 1; Cellular arginine sensor for mTORC1 protein 1; GATS-like protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELHILEHRVRVLSVARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPEDYTLMVDEEGF
KELPPSEFLQVAEATWLVLNVSSHSGAAVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQT
DFILVREQDLSVVIHTLAQEFDIYREVGGEPVPVTRDDSSNGFPRTQHGPSPTVHPIQSP
QNRFCVLTLDPETLPAIATTLIDVLFYSHSTPKEAASSSPEPSSITFFAFSLIEGYISIV
MDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAADISAYYIST
FNFDHALVPEDGIGSVIEVLQRRQEGLAS
Target Bioclass
Other
Family
GATS family
Subcellular location
Cytoplasm, cytosol
Function
Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
Uniprot ID
Q8WTX7
Ensemble ID
ENST00000407689.8
HGNC ID
HGNC:34423

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0232  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0232  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome non-ATPase regulatory subunit 5 (PSMD5) Proteasome subunit S5B/HSM3 family Q16401
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger C2HC domain-containing protein 1A (ZC2HC1A) ZC2HC1 family Q96GY0
Zinc finger C2HC domain-containing protein 1B (ZC2HC1B) ZC2HC1 family Q5TFG8
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1) GATS family Q8WTX7
Translation machinery-associated protein 16 (TMA16) TMA16 family Q96EY4

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.