Details of the Target

General Information of Target

Target ID LDTP09531
Target Name Leucine-rich repeat-containing protein 15 (LRRC15)
Gene Name LRRC15
Gene ID 131578
Synonyms
LIB; Leucine-rich repeat-containing protein 15; Leucine-rich repeat protein induced by beta-amyloid homolog; hLib
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQI
LNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGL
FQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNL
GKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGL
FHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWL
YDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNV
FRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRL
YDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPE
VPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLA
IAAIVIGIVALACSLAACVGCCCCKKRSQAVLMQMKAPNEC
Target Bioclass
Transporter and channel
Subcellular location
Membrane
Function
Modulates the ability of SARS-CoV-2 to infect host cells through interaction with the spike protein. Does not act as a SARS-CoV-2 entry receptor but sequesters virions and antagonizes in trans SARS-CoV-2 infection of ACE2(+) cells when expressed on nearby cells.
Uniprot ID
Q8TF66
Ensemble ID
ENST00000347624.4
HGNC ID
HGNC:20818
ChEMBL ID
CHEMBL4295907

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.W16L .
CCK81 SNV: p.A542V .
HUH1 SNV: p.G538V .
KARPAS422 SNV: p.A143P .
KASUMI1 SNV: p.D410H .
KMCH1 SNV: p.E206D .
MELJUSO SNV: p.L432F .
MEWO SNV: p.M214I .
MFE319 SNV: p.P451S .
NCIH2122 SNV: p.G123S .
NCIH2172 SNV: p.S306T .
NCIH2286 SNV: p.L281M .
NCIH23 SNV: p.L295R .
OVKATE SNV: p.L9M .
SKMM2 SNV: p.S57R .
SW756 SNV: p.N54K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C433(1.52)  LDD3332  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 42-MG-BA C433(2.14)  LDD2244  [1]
 LDCM0023  KB03 42-MG-BA C45(2.06); C433(2.44); C459(3.05)  LDD2661  [1]
 LDCM0024  KB05 MKN45 C433(1.52)  LDD3332  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840