Details of the Target

General Information of Target

Target ID LDTP09519
Target Name Arginine/serine-rich protein PNISR (PNISR)
Gene Name PNISR
Gene ID 25957
Synonyms
C6orf111; SFRS18; SRRP130; Arginine/serine-rich protein PNISR; PNN-interacting serine/arginine-rich protein; SR-related protein; SR-rich protein; Serine/arginine-rich-splicing regulatory protein 130; SRrp130; Splicing factor, arginine/serine-rich 130; Splicing factor, arginine/serine-rich 18
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWDQGGQPWQQWPLNQQQWMQSFQHQQDPSQIDWAALAQAWIAQREASGQQSMVEQPPGM
MPNGQDMSTMESGPNNHGNFQGDSNFNRMWQPEWGMHQQPPHPPPDQPWMPPTPGPMDIV
PPSEDSNSQDSGEFAPDNRHIFNQNNHNFGGPPDNFAVGPVNQFDYQHGAAFGPPQGGFH
PPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGL
EKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENV
EAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKD
AHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIR
QKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVN
EKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSS
GSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRN
SIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEA
KEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERT
FSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSR
SRSVEKSQRSGKKASRKHKSKSRSR
Target Bioclass
Other
Family
Splicing factor SR family
Subcellular location
Nucleus speckle
Uniprot ID
Q8TF01
Ensemble ID
ENST00000369239.10
HGNC ID
HGNC:21222

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 SNV: p.A365V .
DU145 SNV: p.E353D .
HLF SNV: p.R578C .
HT115 SNV: p.R578C .
JURKAT SNV: p.K714Ter .
LNCaP clone FGC SNV: p.Q505R .
MFE319 Insertion: p.E267RfsTer9
SNV: p.S672R		 .
SW403 SNV: p.E254Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		N.A.  LDD2234  [1]

References

1 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377