Details of the Target

General Information of Target

Target ID LDTP09480
Target Name Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8L3)
Gene Name EPS8L3
Gene ID 79574
Synonyms
EPS8R3; Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8-like protein 3; Epidermal growth factor receptor pathway substrate 8-related protein 3; EPS8-related protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ
GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG
LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQRPRLGGLQPGQDRWRGPAMERPLPMEQ
ARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDEE
VLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLGR
LATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESN
LWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSLRRGSHRLGS
TSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVL
DHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQA
ENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP
Target Bioclass
Other
Family
EPS8 family
Subcellular location
Cytoplasm
Uniprot ID
Q8TE67
Ensemble ID
ENST00000361852.8
HGNC ID
HGNC:21297

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.E574K .
DU145 SNV: p.S501R .
HT Deletion: p.N273TfsTer33 .
MCC13 SNV: p.W486Ter .
MDAMB468 SNV: p.P448S .
MFE296 Deletion: p.N273TfsTer33 .
MOLT4 Deletion: p.N440TfsTer14 .
NCIH1155 SNV: p.E152D .
OV90 SNV: p.G513V DBIA    Probe Info 
SG231 SNV: p.C37S .
SNGM Deletion: p.N273TfsTer33 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C37(1.62)  LDD3330  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 769-P C354(1.47); C329(3.43); C572(1.04)  LDD2246  [2]
 LDCM0023  KB03 769-P C354(3.78); C329(5.06); C572(1.33)  LDD2663  [2]
 LDCM0024  KB05 MIA PaCa-2 C37(1.62)  LDD3330  [2]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060