Details of the Target

General Information of Target

Target ID LDTP09479
Target Name A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAMTS18)
Gene Name ADAMTS18
Gene ID 170692
Synonyms
ADAMTS21; A disintegrin and metalloproteinase with thrombospondin motifs 18; ADAM-TS 18; ADAM-TS18; ADAMTS-18; EC 3.4.24.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MECALLLACAFPAAGSGPPRGLAGLGRVAKALQLCCLCCASVAAALASDSSSGASGLNDD
YVFVTPVEVDSAGSYISHDILHNGRKKRSAQNARSSLHYRFSAFGQELHLELKPSAILSS
HFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISP
LPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRE
TEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVV
ADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHH
ADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSC
TINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQ
YLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDI
CKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSE
CSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNS
KPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVC
ELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQ
ELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNET
LVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAIC
LRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQ
KKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKG
SAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCS
EKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCG
GGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQ
HGVCNHKFYGKQCCKSCTRKI
Target Bioclass
Enzyme
Subcellular location
Secreted, extracellular space, extracellular matrix
Uniprot ID
Q8TE60
Ensemble ID
ENST00000282849.10
HGNC ID
HGNC:17110

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
42MGBA SNV: p.A43V .
CAL148 SNV: p.P852L .
CCLP1 SNV: p.C748Ter .
GAMG SNV: p.Q612Ter .
HCC1806 SNV: p.S1187A .
HCT15 SNV: p.E107V; p.S373F .
HEC1 SNV: p.C36G .
HUPT3 Insertion: p.A870PfsTer28 .
IGR1 SNV: p.K966N .
IGR37 SNV: p.S1187F .
IGR39 SNV: p.S1187F .
IGROV1 SNV: p.G590S .
Ishikawa (Heraklio) 02 ER SNV: p.P642H .
KELLY SNV: p.A13T .
KMS12BM SNV: p.G704R .
MCC13 SNV: p.G380S .
MDST8 SNV: p.G470R .
MELJUSO SNV: p.W670Ter .
MEWO SNV: p.H727Y .
MINO SNV: p.P18L .
NCIH661 SNV: p.V299L .
NOMO1 SNV: p.E437K .
ONS76 SNV: p.P264H .
OPM2 SNV: p.R281G .
P31FUJ SNV: p.C254S .
RCC10RGB SNV: p.Y798C .
REH SNV: p.A44V .
RKO SNV: p.A132P .
SH4 SNV: p.D337N .
SW1271 SNV: p.S55R .
TGBC52TKB SNV: p.I634V .
TOV21G SNV: p.E811G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C958(2.97)  LDD3380  [1]
BTD
 Probe Info  		C1079(1.29)  LDD2136  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 OV-90 C958(2.54)  LDD2546  [1]
 LDCM0023  KB03 OV-90 C958(2.68)  LDD2963  [1]
 LDCM0024  KB05 OV-90 C958(2.97)  LDD3380  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1079(1.29)  LDD2136  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761