Details of the Target

General Information of Target

Target ID LDTP09400
Target Name WAP four-disulfide core domain protein 5 (WFDC5)
Gene Name WFDC5
Gene ID 149708
Synonyms
PRG5; WAP1; WAP four-disulfide core domain protein 5; Putative protease inhibitor WAP1; p53-responsive gene 5 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRTQSLLLLGALLAVGSQLPAVFGRKKGEKSGGCPPDDGPCLLSVPDQCVEDSQCPLTRK
CCYRACFRQCVPRVSVKLGSCPEDQLRCLSPMNHLCHKDSDCSGKKRCCHSACGRDCRDP
ARGTAPGCPGQANSDLGSVALHLSWGPTERVHDGRPGALPAGQHYLYQRWFQPSDNHWPA
DTSLQPIHPWFLLLGVKVHSLSSEEGLCITPVLCTTAIRASHPS
Target Bioclass
Other
Subcellular location
Secreted
Function Putative acid-stable proteinase inhibitor.
Uniprot ID
Q8TCV5
Ensemble ID
ENST00000307971.7
HGNC ID
HGNC:20477

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0167  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0573  Fragment11 Ramos C128(0.81)  LDD2190  [2]
 LDCM0576  Fragment14 Ramos C128(2.82)  LDD2193  [2]
 LDCM0586  Fragment28 Ramos C128(0.62)  LDD2198  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Collagen alpha-1(VIII) chain (COL8A1) . P27658
Kelch-like protein 38 (KLHL38) . Q2WGJ6

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578