Details of the Target

General Information of Target

Target ID LDTP09398
Target Name Glutamate receptor ionotropic, NMDA 3A (GRIN3A)
Gene Name GRIN3A
Gene ID 116443
Synonyms
KIAA1973; Glutamate receptor ionotropic, NMDA 3A; GluN3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR3A; NR3A; NMDAR-L
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTT
APRAASRAPDDSRAGAQRDEPEPGTRRSPAPSPGARWLGSTLHGRGPPGSRKPGEGARAE
ALWPRDALLFAVDNLNRVEGLLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSF
LQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNPLHLQL
SLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITAN
LPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQ
NVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCM
EVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTR
LGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAG
QLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIV
GDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTR
DTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSAL
NICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGI
HDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLD
AFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFM
DMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLL
PRIKNKSKLQYWLHTSQRLHRAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLS
HDNRRKYIFSDEEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVMQELS
ELEKQIQVIRQELQLAVSRKTELEEYQRTSRTCES
Target Bioclass
Transporter and channel
Family
Glutamate-gated ion channel (TC 1.A.10.1) family, NR3A/GRIN3A subfamily
Subcellular location
Cell membrane
Function
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. During the development of neural circuits, plays a role in the synaptic refinement period, restricting spine maturation and growth. By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses. May also play a role in PPP2CB-NMDAR mediated signaling mechanism.
Uniprot ID
Q8TCU5
Ensemble ID
ENST00000361820.6
HGNC ID
HGNC:16767
ChEMBL ID
CHEMBL4787

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0217  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0224  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 26 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acamprosate Small molecular drug DB00659
Acetylcysteine Small molecular drug DB06151
Amantadine Small molecular drug DB00915
Aripiprazole Small molecular drug DB01238
Atomoxetine Small molecular drug DB00289
Dextromethorphan Small molecular drug DB00514
Dextropropoxyphene Small molecular drug DB00647
Donepezil Small molecular drug DB00843
Enflurane Small molecular drug DB00228
Ethanol Small molecular drug DB00898
Glutamic Acid Small molecular drug DB00142
Halothane Small molecular drug DB01159
Ketamine Small molecular drug DB01221
Memantine Small molecular drug DB01043
Methadone Small molecular drug DB00333
Milnacipran Small molecular drug DB04896
Orphenadrine Small molecular drug DB01173
Pentobarbital Small molecular drug DB00312
Phenobarbital Small molecular drug DB01174
Prasterone Small molecular drug DB01708
Procaine Small molecular drug DB00721
Profenamine Small molecular drug DB00392
Secobarbital Small molecular drug DB00418
Tramadol Small molecular drug DB00193
Esketamine . DB11823
Fluciclovine (18f) . DB13146
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ketobemidone Small molecular drug DB06738
Neramexane Small molecular drug DB04926
Discontinued
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phencyclidine Small molecular drug DB03575
Rolicyclidine Small molecular drug DB01549
Tenocyclidine Small molecular drug DB01520

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.