Details of the Target
General Information of Target
| Target ID | LDTP09392 | |||||
|---|---|---|---|---|---|---|
| Target Name | Phosphoethanolamine/phosphocholine phosphatase (PHOSPHO1) | |||||
| Gene Name | PHOSPHO1 | |||||
| Gene ID | 162466 | |||||
| Synonyms |
Phosphoethanolamine/phosphocholine phosphatase; EC 3.1.3.75 |
|||||
| 3D Structure | ||||||
| Sequence |
MSGCFPVSGLRCLSRDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLR
ATYREGFYNEYMQRVFKYLGEQGVRPRDLSAIYEAIPLSPGMSDLLQFVAKQGACFEVIL ISDANTFGVESSLRAAGHHSLFRRILSNPSGPDARGLLALRPFHTHSCARCPANMCKHKV LSDYLRERAHDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEP SSFRASVVPWETAADVRLHLQQVLKSC |
|||||
| Target Bioclass |
Enzyme
|
|||||
| Family |
HAD-like hydrolase superfamily, PHOSPHO family
|
|||||
| Subcellular location |
Extracellular vesicle
|
|||||
| Function |
Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization. Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix.
|
|||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C234(1.00) | LDD3382 | [1] | |
|
IA-alkyne Probe Info |
 |
N.A. | LDD0166 | [2] | |
|
VSF Probe Info |
 |
N.A. | LDD0007 | [3] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References