Details of the Target

General Information of Target

Target ID LDTP09385
Target Name Palmitoyl thioesterase CPT1C (CPT1C)
Gene Name CPT1C
Gene ID 126129
Synonyms
CATL1; Palmitoyl thioesterase CPT1C; EC 3.1.2.22; Carnitine O-palmitoyltransferase 1, brain isoform; CPTI-B; Carnitine palmitoyltransferase 1C; Carnitine palmitoyltransferase I; CPT I-C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEAHQAVGFRPSLTSDGAEVELSAPVLQEIYLSGLRSWKRHLSRFWNDFLTGVFPASPL
SWLFLFSAIQLAWFLQLDPSLGLMEKIKELLPDWGGQHHGLRGVLAAALFASCLWGALIF
TLHVALRLLLSYHGWLLEPHGAMSSPTKTWLALVRIFSGRHPMLFSYQRSLPRQPVPSVQ
DTVRKYLESVRPILSDEDFDWTAVLAQEFLRLQASLLQWYLRLKSWWASNYVSDWWEEFV
YLRSRNPLMVNSNYYMMDFLYVTPTPLQAARAGNAVHALLLYRHRLNRQEIPPTLLMGMR
PLCSAQYEKIFNTTRIPGVQKDYIRHLHDSQHVAVFHRGRFFRMGTHSRNSLLSPRALEQ
QFQRILDDPSPACPHEEHLAALTAAPRGTWAQVRTSLKTQAAEALEAVEGAAFFVSLDAE
PAGLTREDPAASLDAYAHALLAGRGHDRWFDKSFTLIVFSNGKLGLSVEHSWADCPISGH
MWEFTLATECFQLGYSTDGHCKGHPDPTLPQPQRLQWDLPDQIHSSISLALRGAKILSEN
VDCHVVPFSLFGKSFIRRCHLSSDSFIQIALQLAHFRDRGQFCLTYESAMTRLFLEGRTE
TVRSCTREACNFVRAMEDKEKTDPQCLALFRVAVDKHQALLKAAMSGQGVDRHLFALYIV
SRFLHLQSPFLTQVHSEQWQLSTSQIPVQQMHLFDVHNYPDYVSSGGGFGPADDHGYGVS
YIFMGDGMITFHISSKKSSTKTDSHRLGQHIEDALLDVASLFQAGQHFKRRFRGSGKENS
RHRCGFLSRQTGASKASMTSTDF
Target Bioclass
Enzyme
Family
Carnitine/choline acetyltransferase family
Subcellular location
Mitochondrion outer membrane
Function
Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1. Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner. Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control. Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels.
Uniprot ID
Q8TCG5
Ensemble ID
ENST00000323446.9
HGNC ID
HGNC:18540

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 SNV: p.D542Y .
BT549 SNV: p.G707S .
CCFSTTG1 SNV: p.G443S .
COLO792 Substitution: p.G765R .
COLO800 SNV: p.L433W; p.A435D .
CORL23 SNV: p.T791S .
EFO27 Insertion: p.V104GfsTer35 .
HCC1419 SNV: p.P264S .
HT115 SNV: p.R652H .
IGROV1 SNV: p.M249T .
JURKAT SNV: p.I659T .
MOLT4 SNV: p.P505S .
RKO SNV: p.W219L .
RL952 SNV: p.R340Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C373(2.16)  LDD3340  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 42-MG-BA C373(1.42)  LDD2244  [1]
 LDCM0023  KB03 A204 C610(2.78); C373(1.65)  LDD2669  [1]
 LDCM0024  KB05 NB1 C373(2.16)  LDD3340  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840