Details of the Target

General Information of Target

Target ID LDTP09371
Target Name Meiosis 1 arrest protein (M1AP)
Gene Name M1AP
Gene ID 130951
Synonyms
C2orf65; SPATA37; Meiosis 1 arrest protein; Meiosis 1-arresting protein; Meiosis 1-associated protein; Spermatogenesis-associated protein 37
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHPGRTTGKGPSTHTQIDQQPPRLLIVHIALPSWADICTNLCEALQNFFSLACSLMGPSR
MSLFSLYMVQDQHECILPFVQVKGNFARLQTCISELRMLQREGCFRSQGASLRLAVEDGL
QQFKQYSRHVTTRAALTYTSLEITILTSQPGKEVVKQLEEGLKDTDLARVRRFQVVEVTK
GILEHVDSASPVEDTSNDESSILGTDIDLQTIDNDIVSMEIFFKAWLHNSGTDQEQIHLL
LSSQCFSNISRPRDNPMCLKCDLQERLLCPSLLAGTADGSLRMDDPKGDFITLYQMASQS
SASHYKLQVIKALKSSGLCESLTYGLPFILRPTSCWQLDWDELETNQQHFHALCHSLLKR
EWLLLAKGEPPGPGHSQRIPASTFYVIMPSHSLTLLVKAVATRELMLPSTFPLLPEDPHD
DSLKNVESMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKHPCKTG
QLQTNRARATVAPLPMTPVPGRASKMPAASKSSSDAFFLPSEWEKDPSRP
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Required for meiosis I progression during spermatogenesis.
Uniprot ID
Q8TC57
Ensemble ID
ENST00000290536.9
HGNC ID
HGNC:25183

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL72 SNV: p.P58A .
HCT15 SNV: p.Q121H .
MCC13 SNV: p.E220K; p.F222L .
NB4 SNV: p.D285E .
NCIH446 SNV: p.C319Ter .
OCUM1 SNV: p.R253K .
U937 SNV: p.Q347Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C261(1.28)  LDD1702  [1]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C261(1.28)  LDD1702  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
DNA-directed RNA polymerase III subunit RPC7-like (POLR3GL) Eukaryotic RPC7 RNA polymerase subunit family Q9BT43
Ubiquitin-like protein 3 (UBL3) . O95164
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 740 (ZNF740) Krueppel C2H2-type zinc-finger protein family Q8NDX6
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Desmin (DES) Intermediate filament family P17661
Lamin-B1 (LMNB1) Intermediate filament family P20700
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
Meiosis 1 arrest protein (M1AP) . Q8TC57
Pleckstrin homology domain-containing family A member 2 (PLEKHA2) . Q9HB19

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.