Details of the Target

General Information of Target

Target ID LDTP09357
Target Name Cilia- and flagella-associated protein 251 (CFAP251)
Gene Name CFAP251
Gene ID 144406
Synonyms
WDR66; Cilia- and flagella-associated protein 251; WD repeat-containing protein 66
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDAAEAPREATGENGETEMKEEEEPNPNYKEVEDPQQESKDDTIAWRESQEEERKTGEE
EGEEEGKEDKKIVMEETEEKAGEVQEKEASGIQEETTVEPQEVTASMIRLETQITDSQSI
TSGIFPKTQRGSKSKLSLQLEDAETDELLRDLSTQIEFLDLDQISPEEQQISSPERQPSG
ELEEKTDRMPQDELGQERRDLEPENREEGQERRVSDIQSKAGISRESLVSSTTEDILFQK
DKSTPVYPLTMTWSFGWNSSLPVYYIREERQRVLLYVCAHTAIIYNVFRNNQYHLQGHAN
IISCLCVSEDRRWIATADKGPDCLVIIWDSFTGIPVHTIFDSCPEGNGIMAMAMTHDAKY
LATISDAEVQKVCIWKWTLAVETPACTLELPTEYGVQNYVTFNPTNNKELVSNSKTRAIY
YAWYEERDTLAHSAPLLTEKTFNKLVGKFSQSIFHLNLTQILSATMEGKLVVWDIHRPPS
SASTFLGFPYIKPCKLVHLQKEGITVLTTIDSYIVTGDIKGNIKFYDHTLSIVNWYSHLK
LGAIRTLSFSKTPATPPTEKSNYPPDCTLKGDLFVLRNFIIGTSDAAVYHLTTDGTKLEK
LFVEPKDAICAISCHPYQPLIAIGSICGMIKVWNYENKQYLFSRVFEKGLGVQSLTYNPE
GALLGAGFTEGTVYILDAMSLENESPEPFKYSRTSVTHISFSHDSQYMATADRSFTVAVY
MLVVRNGQRVWEYLARLRSHRKSIRSLLFGVYLDSNEPRLLSLGTDRLLIEYDLLRSYKD
HLEVLDIHHTDQGCYPTCMVWYPPLTRELFLLICNSGYKVKLFNATTKMCRKTLLGPAYG
SPIEQTQVLPVRSMAELQKRYLVFINRDKVGLQILPVDGNPHKTSAIVCHPNGVAGMAVS
YDGCYAFTAGGHDRSVVQWKITLSVLEAAVSLGGEDLTPFYGLLSGGREGKFYRELEDYF
YYSQLRSQGIDTMETRKVSEHICLSELPFVMRAIGFYPSEEKIDDIFNEIKFGEYVDTGK
LIDKINLPDFLKVYLNHKPPFGNTMSGIHKSFEVLGYTNSKGKKAIRREDFLRLLVTKGE
HMTEEEMLDCFASLFGLNPEGWKSEPATCSVKGSEICLEEELPDEITAEIFATEILGLTI
SEDSGQDGQ
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, cilium axoneme
Function Involved in spermatozoa motility. May also regulate cilium motility through its role in the assembly of the axonemal radial spokes.
Uniprot ID
Q8TBY9
Ensemble ID
ENST00000288912.9
HGNC ID
HGNC:28506

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.A906T .
CAL51 SNV: p.A587E .
HT SNV: p.D1089G .
KMS12BM SNV: p.N443S .
KYSE30 SNV: p.K492M .
LS180 SNV: p.V506A .
MCAS SNV: p.K779R .
MOLT4 SNV: p.A622T; p.R745Ter; p.D868Y; p.P1099S .
NUGC3 SNV: p.S1051R .
OCUM1 SNV: p.S342R .
OVKATE SNV: p.L775I .
RKO Deletion: p.G571VfsTer6 .
RL952 SNV: p.T1044A .
SKMEL24 SNV: p.G1019E .
SNU1 SNV: p.E1125Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C814(5.45)  LDD3459  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 SW756 C814(2.57)  LDD2625  [1]
 LDCM0023  KB03 SW756 C814(5.64)  LDD3042  [1]
 LDCM0024  KB05 SW756 C814(5.45)  LDD3459  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840