Details of the Target

General Information of Target

Target ID LDTP09339
Target Name Zinc finger and SCAN domain-containing protein 18 (ZSCAN18)
Gene Name ZSCAN18
Gene ID 65982
Synonyms
ZNF447; Zinc finger and SCAN domain-containing protein 18; Zinc finger protein 447
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLPLEKAFASPRSSPAPPDLPTPGSAAGVQQEEPETIPERTPADLEFSRLRFREFVYQEA
AGPHQTLARLHELCRQWLMPEARSKEQMLELLVLEQFLGILPDKVRPWVVAQYPESCKKA
ASLVEGLADVLEEPGMLLGSPAGSSSILSDGVYERHMDPLLLPGELASPSQALGAGEIPA
PSETPWLSPDPLFLEQRRVREAKTEEDGPANTEQKLKSFPEDPQHLGEWGHLDPAEENLK
SYRKLLLWGYQLSQPDAASRLDTEELRLVERDPQGSSLPEGGRRQESAGCACEEAAPAGV
LPELPTEAPPGDALADPPSGTTEEEEEQPGKAPDPQDPQDAESDSATGSQRQSVIQQPAP
DRGTAKLGTKRPHPEDGDGQSLEGVSSSGDSAGLEAGQGPGADEPGLSRGKPYACGECGE
AFAWLSHLMEHHSSHGGRKRYACQGCWKTFHFSLALAEHQKTHEKEKSYALGGARGPQPS
TREAQAGARAGGPPESVEGEAPPAPPEAQR
Target Bioclass
Other
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q8TBC5
Ensemble ID
ENST00000240727.10
HGNC ID
HGNC:21037

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.E228K .
CCK81 SNV: p.P234H .
HDMYZ SNV: p.E90Q .
HDQP1 SNV: p.G208V .
HT115 SNV: p.A298V .
IGROV1 SNV: p.Q274Ter .
Ishikawa (Heraklio) 02 ER Deletion: p.G473AfsTer54 .
LNCaP clone FGC SNV: p.P179S .
LS513 SNV: p.E213K .
NCIH1993 SNV: p.G99V .
TOV21G SNV: p.A504E .
U937 SNV: p.P181H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C173(1.32)  LDD3313  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 13.63  LDD0403  [1]
 LDCM0022  KB02 A204 C173(2.17)  LDD2252  [2]
 LDCM0023  KB03 A204 C173(3.83)  LDD2669  [2]
 LDCM0024  KB05 Hs 936.T C173(1.32)  LDD3313  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ferredoxin-fold anticodon-binding domain-containing protein 1 (FDXACB1) . Q9BRP7
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and SCAN domain-containing protein 22 (ZSCAN22) Krueppel C2H2-type zinc-finger protein family P10073
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Suppressor of fused homolog (SUFU) SUFU family Q9UMX1
EPM2A-interacting protein 1 (EPM2AIP1) . Q7L775
PiggyBac transposable element-derived protein 1 (PGBD1) . Q96JS3
SCAN domain-containing protein 1 (SCAND1) . P57086

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840