Details of the Target

General Information of Target

Target ID LDTP09334
Target Name THAP domain-containing protein 6 (THAP6)
Gene Name THAP6
Gene ID 152815
Synonyms
THAP domain-containing protein 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVKCCSAIGCASRCLPNSKLKGLTFHVFPTDENIKRKWVLAMKRLDVNAAGIWEPKKGDV
LCSRHFKKTDFDRSAPNIKLKPGVIPSIFDSPYHLQGKREKLHCRKNFTLKTVPATNYNH
HLVGASSCIEEFQSQFIFEHSYSVMDSPKKLKHKLDHVIGELEDTKESLRNVLDREKRFQ
KSLRKTIRELKDECLISQETANRLDTFCWDCCQESIEQDYIS
Target Bioclass
Transcription factor
Uniprot ID
Q8TBB0
Ensemble ID
ENST00000311638.7
HGNC ID
HGNC:23189

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IPC298 SNV: p.S222L .
RKO Deletion: p.S12del
SNV: p.R64M		 .
SKMEL5 SNV: p.P55L .
T98G SNV: p.Y142D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C10(0.92)  LDD2129  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C10(0.92)  LDD2129  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761