Details of the Target
General Information of Target
| Target ID | LDTP09313 | |||||
|---|---|---|---|---|---|---|
| Target Name | Fibroblast growth factor-binding protein 3 (FGFBP3) | |||||
| Gene Name | FGFBP3 | |||||
| Gene ID | 143282 | |||||
| Synonyms |
C10orf13; Fibroblast growth factor-binding protein 3; FGF-BP3; FGF-binding protein 3; FGFBP-3 |
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| 3D Structure | ||||||
| Sequence |
MTPPKLRASLSPSLLLLLSGCLLAAARREKGAASNVAEPVPGPTGGSSGRFLSPEQHACS
WQLLLPAPEAAAGSELALRCQSPDGARHQCAYRGHPERCAAYAARRAHFWKQVLGGLRKK RRPCHDPAPLQARLCAGKKGHGAELRLVPRASPPARPTVAGFAGESKPRARNRGRTRERA SGPAAGTPPPQSAPPKENPSERKTNEGKRKAALVPNEERPMGTGPDPDGLDGNAELTETY CAEKWHSLCNFFVNFWNG |
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| Target Bioclass |
Other
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| Family |
Fibroblast growth factor-binding protein family
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| Subcellular location |
Secreted
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| Function |
Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C80(2.95); C90(3.41) | LDD2460 | [1] | |
Competitor(s) Related to This Target