General Information of Target

Target ID LDTP09310
Target Name M-phase-specific PLK1-interacting protein (MPLKIP)
Gene Name MPLKIP
Gene ID 136647
Synonyms
C7orf11; TTDN1; M-phase-specific PLK1-interacting protein; TTD non-photosensitive 1 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQRQNFRPPTPPYPGPGGGGWGSGSSFRGTPGGGGPRPPSPRDGYGSPHHTPPYGPRSRP
YGSSHSPRHGGSFPGGRFGSPSPGGYPGSYSRSPAGSQQQFGYSPGQQQTHPQGSPRTST
PFGSGRVREKRMSNELENYFKPSMLEDPWAGLEPVSVVDISQQYSNTQTFTGKKGRYFC
Target Bioclass
Other
Subcellular location
Nucleus
Function May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.
Uniprot ID
Q8TAP9
Ensemble ID
ENST00000306984.8
HGNC ID
HGNC:16002

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
5E-2FA
 Probe Info 
N.A.  LDD2235  [1]
m-APA
 Probe Info 
N.A.  LDD2231  [1]
AOyne
 Probe Info 
13.50  LDD0443  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8

References

1 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
2 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.