Details of the Target

General Information of Target

Target ID LDTP09296
Target Name Potassium voltage-gated channel subfamily G member 3 (KCNG3)
Gene Name KCNG3
Gene ID 170850
Synonyms
Potassium voltage-gated channel subfamily G member 3; Voltage-gated potassium channel subunit Kv10.1; Voltage-gated potassium channel subunit Kv6.3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTFGRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNE
YFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRM
SDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVF
VIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRF
IVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVI
KLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSI
PAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELK
FRSARYSRSLSTEFLN
Target Bioclass
Transporter and channel
Family
Potassium channel family, G (TC 1.A.1.2) subfamily, Kv6.3/KCNG3 sub-subfamily
Subcellular location
Cell membrane
Function
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1.
Uniprot ID
Q8TAE7
Ensemble ID
ENST00000306078.2
HGNC ID
HGNC:18306
ChEMBL ID
CHEMBL2362996

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.A148V .
HCT15 SNV: p.Y61C .
HEC1 SNV: p.A18T .
HUH7 SNV: p.I73F .
KU1919 SNV: p.R5H .
LN18 SNV: p.V324A .
MDAMB231 SNV: p.A284T .
MFE319 SNV: p.M294V .
MOLT4 SNV: p.R58H; p.R119H .
NCIH1944 SNV: p.V183L .
NUGC3 SNV: p.G217E .
SNU1 SNV: p.R141H .
SW620 SNV: p.S21L .
TOV21G SNV: p.L26M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K82(10.00)  LDD0277  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270