Details of the Target

General Information of Target

Target ID LDTP09265
Target Name GTPase IMAP family member 7 (GIMAP7)
Gene Name GIMAP7
Gene ID 168537
Synonyms
IAN7; GTPase IMAP family member 7; Immunity-associated nucleotide 7 protein; IAN-7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAESEDRSLRIVLVGKTGSGKSATANTILGEEIFDSRIAAQAVTKNCQKASREWQGRDLL
VVDTPGLFDTKESLDTTCKEISRCIISSCPGPHAIVLVLLLGRYTEEEQKTVALIKAVFG
KSAMKHMVILFTRKEELEGQSFHDFIADADVGLKSIVKECGNRCCAFSNSKKTSKAEKES
QVQELVELIEKMVQCNEGAYFSDDIYKDTEERLKQREEVLRKIYTDQLNEEIKLVEEDKH
KSEEEKEKEIKLLKLKYDEKIKNIREEAERNIFKDVFNRIWKMLSEIWHRFLSKCKFYSS
Target Bioclass
Enzyme
Family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, AIG1/Toc34/Toc159-like paraseptin GTPase family, IAN subfamily
Subcellular location
Lipid droplet
Function The dimer has GTPase activity; the active site contains residues from both subunits.
Uniprot ID
Q8NHV1
Ensemble ID
ENST00000313543.5
HGNC ID
HGNC:22404

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [1]
IA-alkyne
 Probe Info  		C78(0.00); C195(0.00)  LDD0036  [1]
Lodoacetamide azide
 Probe Info  		C78(0.00); C195(0.00)  LDD0037  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 T cell-activated C164, C165(5.30)  LDD1704  [2]
 LDCM0024  KB05 T cell C78(5.09)  LDD1705  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GTPase IMAP family member 2 (GIMAP2) AIG1/Toc34/Toc159-like paraseptin GTPase family Q9UG22
GTPase IMAP family member 7 (GIMAP7) AIG1/Toc34/Toc159-like paraseptin GTPase family Q8NHV1

References

1 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.