Details of the Target
General Information of Target
| Target ID | LDTP09238 | |||||
|---|---|---|---|---|---|---|
| Target Name | E3 ubiquitin-protein ligase TRIM58 (TRIM58) | |||||
| Gene Name | TRIM58 | |||||
| Gene ID | 25893 | |||||
| Synonyms |
E3 ubiquitin-protein ligase TRIM58; EC 2.3.2.27; Protein BIA2; RING-type E3 ubiquitin transferase TRIM58; Tripartite motif-containing protein 58 |
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| 3D Structure | ||||||
| Sequence |
MAWAPPGERLREDARCPVCLDFLQEPVSVDCGHSFCLRCISEFCEKSDGAQGGVYACPQC
RGPFRPSGFRPNRQLAGLVESVRRLGLGAGPGARRCARHGEDLSRFCEEDEAALCWVCDA GPEHRTHRTAPLQEAAGSYQVKLQMALELMRKELEDALTQEANVGKKTVIWKEKVEMQRQ RFRLEFEKHRGFLAQEEQRQLRRLEAEERATLQRLRESKSRLVQQSKALKELADELQERC QRPALGLLEGVRGVLSRSKAVTRLEAENIPMELKTACCIPGRRELLRKFQVDVKLDPATA HPSLLLTADLRSVQDGEPWRDVPNNPERFDTWPCILGLQSFSSGRHYWEVLVGEGAEWGL GVCQDTLPRKGETTPSPENGVWALWLLKGNEYMVLASPSVPLLQLESPRCIGIFLDYEAG EISFYNVTDGSYIYTFNQLFSGLLRPYFFICDATPLILPPTTIAGSGNWASRDHLDPASD VRDDHL |
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| Target Bioclass |
Enzyme
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| Family |
TRIM/RBCC family
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| Function |
E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C240(3.95) | LDD3345 | [1] | |
Competitor(s) Related to This Target