Details of the Target

General Information of Target

Target ID LDTP09174
Target Name Transient receptor potential cation channel subfamily V member 3 (TRPV3)
Gene Name TRPV3
Gene ID 162514
Synonyms
Transient receptor potential cation channel subfamily V member 3; TrpV3; Vanilloid receptor-like 3; VRL-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTS
PPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLK
KRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNIN
PNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGAD
VNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNIL
HALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYI
LSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEML
TLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMG
WLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLY
LFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLG
FGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLIT
YVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGEL
CKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFE
EVEEFPETSV
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
Transient receptor (TC 1.A.4) family, TrpV subfamily, TRPV3 sub-subfamily
Subcellular location
Membrane
Function
Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).
TTD ID
T58496
Uniprot ID
Q8NET8
DrugMap ID
TT946IA
Ensemble ID
ENST00000301365.8
HGNC ID
HGNC:18084
ChEMBL ID
CHEMBL5522

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.P86S .
HCT15 SNV: p.P54L .
HT115 SNV: p.K169N .
KASUMI2 SNV: p.A243V .
LS513 SNV: p.A269E .
MELJUSO SNV: p.H439Y .
NCIH82 Deletion: p.T37QfsTer11 .
OCUG1 SNV: p.H417Q .
OZ SNV: p.A194V .
RL952 SNV: p.M323I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		H4(0.00); M8(0.00); M12(0.00)  LDD0245  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Camphor Small molecular drug DB01744
Cannabidiol Small molecular drug DB09061
Eugenol Small molecular drug DB09086
Levomenthol Small molecular drug DB00825
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sar292833 . D03SLK
Investigative
Click To Hide/Show 17 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-apb Small molecular drug D00HCI
6-tert-butyl-m-cresol Small molecular drug D0F0BB
Aspirin-triggered Resolvin D1 Small molecular drug D05PYO
Borneol Small molecular drug D0P8RH
Carvacrol Small molecular drug D07JDC
Carveol Small molecular drug D03EYA
Cinnamaldehyde Small molecular drug D0PJ3M
Citral Small molecular drug D00VWN
Dihydrocarveol Small molecular drug D07GOR
Diphenylboronic Anhydride Small molecular drug D03TWR
Diphenyltetrahydrofuran Small molecular drug D01BDJ
Incensole Acetate Small molecular drug D0JW1C
Nabiximols Small molecular drug DB14011
Tetrahydrocannabivarin Small molecular drug D0D8PZ
(S)-camphor . DB11345
Edp-18 . D0H0EP
Medical Cannabis . DB14009

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.