Details of the Target
General Information of Target
| Target ID | LDTP09170 | |||||
|---|---|---|---|---|---|---|
| Target Name | Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe (LFNG) | |||||
| Gene Name | LFNG | |||||
| Gene ID | 3955 | |||||
| Synonyms |
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; EC 2.4.1.222; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
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| 3D Structure | ||||||
| Sequence |
MLKRCGRRLLLALAGALLACLLVLTADPPPPPLPAERGRRALRSLAGPAGAAPAPGLGAA
AAAPGALVRDVHSLSEYFSLLTRARRDAGPPPGAAPRPADGHPRPLAEPLAPRDVFIAVK TTKKFHRARLDLLLETWISRHKEMTFIFTDGEDEALARHTGNVVITNCSAAHSRQALSCK MAVEYDRFIESGRKWFCHVDDDNYVNLRALLRLLASYPHTRDVYVGKPSLDRPIQAMERV SENKVRPVHFWFATGGAGFCISRGLALKMSPWASGGHFMNTAERIRLPDDCTIGYIVEAL LGVPLIRSGLFHSHLENLQQVPTSELHEQVTLSYGMFENKRNAVHVKGPFSVEADPSRFR SIHCHLYPDTPWCPRTAIF |
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| Target Bioclass |
Enzyme
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| Family |
Glycosyltransferase 31 family
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| Subcellular location |
Golgi apparatus membrane
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| Function |
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C50(1.55) | LDD3314 | [1] | |
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IA-alkyne Probe Info |
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N.A. | LDD0162 | [2] | |
Competitor(s) Related to This Target
References