Details of the Target

General Information of Target

Target ID LDTP09169
Target Name Activin receptor type-1C (ACVR1C)
Gene Name ACVR1C
Gene ID 130399
Synonyms
ALK7; Activin receptor type-1C; EC 2.7.11.30; Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7; ALK-7
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI
KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITV
PVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSG
SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ
TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA
SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN
PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD
MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK
TISQLCVKEDCKA
Target Bioclass
Enzyme
Family
Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
Subcellular location
Membrane
Function
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Uniprot ID
Q8NER5
Ensemble ID
ENST00000243349.13
HGNC ID
HGNC:18123
ChEMBL ID
CHEMBL5642

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 SNV: p.V435F .
NB4 SNV: p.K347N .
RL952 SNV: p.R193K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C517(2.94)  LDD3339  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C215(0.84)  LDD1509  [2]
 LDCM0278  AC19 HEK-293T C215(0.98)  LDD1517  [2]
 LDCM0287  AC27 HEK-293T C215(0.96)  LDD1526  [2]
 LDCM0290  AC3 HEK-293T C215(0.87)  LDD1529  [2]
 LDCM0296  AC35 HEK-293T C215(0.98)  LDD1535  [2]
 LDCM0305  AC43 HEK-293T C215(0.88)  LDD1544  [2]
 LDCM0314  AC51 HEK-293T C215(0.96)  LDD1553  [2]
 LDCM0322  AC59 HEK-293T C215(0.96)  LDD1561  [2]
 LDCM0406  CL19 HEK-293T C215(1.00)  LDD1610  [2]
 LDCM0420  CL31 HEK-293T C215(0.96)  LDD1624  [2]
 LDCM0433  CL43 HEK-293T C215(0.91)  LDD1637  [2]
 LDCM0446  CL55 HEK-293T C215(0.96)  LDD1649  [2]
 LDCM0459  CL67 HEK-293T C215(0.94)  LDD1662  [2]
 LDCM0462  CL7 HEK-293T C215(1.06)  LDD1665  [2]
 LDCM0472  CL79 HEK-293T C215(0.90)  LDD1675  [2]
 LDCM0486  CL91 HEK-293T C215(0.89)  LDD1689  [2]
 LDCM0022  KB02 CCK-81 C517(2.32)  LDD2297  [1]
 LDCM0023  KB03 CCK-81 C517(3.05)  LDD2714  [1]
 LDCM0024  KB05 NALM-6 C517(2.94)  LDD3339  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402