Details of the Target

General Information of Target

Target ID LDTP09160
Target Name Terminal nucleotidyltransferase 5D (TENT5D)
Gene Name TENT5D
Gene ID 169966
Synonyms
FAM46D; Terminal nucleotidyltransferase 5D; EC 2.7.7.19; Non-canonical poly(A) polymerase FAM46D
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEIRFTNLTWDQVITLDQVLDEVIPIHGKGNFPTMEVKPKDIIHVVKDQLIGQGIIVKD
ARLNGSVASYILASHNGISYKDLDVIFGVELPGNEEFQVVKDAVLDCLLDFLPKDVKKEK
LSPDIMKDAYVQKLVKVCNGHDCWSLISLSNNTGKNLELKFVSSLRRQFEFSVDSFQIVL
DPMLDFYSDKNAKLTKESYPVVVAESMYGDFQEAMTHLQHKLICTRKPEEIRGGGLLKYC
SLLVHGFKPACMSEIKNLERYMCSRFFIDFPHIEEQQKKIESYLHNHFIGEGMTKYDYLM
TLHGVVNESTVCLMSYERRQILHLITMMALKVLGELNILPNTQKVTCFYQPAPYFAAEAR
YPIYVIPEPPPVSFQPYHPLHFRGSNGMS
Target Bioclass
Enzyme
Family
TENT family
Function Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group.
Uniprot ID
Q8NEK8
Ensemble ID
ENST00000308293.6
HGNC ID
HGNC:28399

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C240(17.49)  LDD0315  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0023  KB03 Jurkat C240(17.49)  LDD0315  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) Protein-tyrosine phosphatase family P26045
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) HEY family Q9Y5J3
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MSX-2 (MSX2) Msh homeobox family P35548
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DPY30 domain-containing protein 2 (DYDC2) Dpy-30 family Q96IM9
Keratin-associated protein 19-2 (KRTAP19-2) KRTAP type 19 family Q3LHN2
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 11-1 (KRTAP11-1) PMG family Q8IUC1
Polyadenylate-binding protein 3 (PABPC3) Polyadenylate-binding protein type-1 family Q9H361
Puratrophin-1 (PLEKHG4) . Q58EX7
Ras association domain-containing protein 3 (RASSF3) . Q86WH2
Uncharacterized protein C10orf55 (C10orf55) . Q5SWW7
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060