Details of the Target

General Information of Target

Target ID	LDTP09148
Target Name	Homeodomain-interacting protein kinase 4 (HIPK4)
Gene Name	HIPK4
Gene ID	147746
Synonyms	Homeodomain-interacting protein kinase 4; EC 2.7.11.1
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSTIQSETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLH CMRGLDPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQV LTALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRF YRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLH AACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVA SRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH YYQLSLRSYRLSLQVEGKPPTPVVAAEDGTPYYCLAEEKEAAGMGSVAGSSPFFREEKAP GMQRAIDQLDDLSLQEAGHGLWGETCTNAVSDMMVPLKAAITGHHVPDSGPEPILAFYSS RLAGRHKARKPPAGSKSDSNFSNLIRLSQVSPEDDRPCRGSSWEEGEHLGASAEPLAILQ RDEDGPNIDNMTMEAERPDPELFDPSSCPGEWLSEPDCTLESVRGPRAQGLPPRRSHQHG PPRGATSFLQHVTGHH
Target Bioclass	Enzyme
Family	Protein kinase superfamily, CMGC Ser/Thr protein kinase family, HIPK subfamily
Subcellular location	Cytoplasm
Function	Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter. May act as a corepressor of transcription factors (Potential). {, }.
Uniprot ID	Q8NE63
Ensemble ID	ENST00000291823.3
HGNC ID	HGNC:19007
ChEMBL ID	CHEMBL1075167

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
CY-1 Probe Info			N.A.	LDD0246	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Heat shock protein HSP 90-beta (HSP90AB1)				Heat shock protein 90 family	P08238

Other

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Amyloid protein-binding protein 2 (APPBP2)				.	Q92624

References

1	Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.