Details of the Target

General Information of Target

Target ID LDTP09146
Target Name Protein FAM13C (FAM13C)
Gene Name FAM13C
Gene ID 220965
Synonyms
FAM13C1; Protein FAM13C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFSCFCFSLQDNSFSSTTVTECDEDPVSLHEDQTDCSSLRDENNKENYPDAGALVEEHAP
PSWEPQQQNVEATVLVDSVLRPSMGNFKSRKPKSIFKAESGRSHGESQETEHVVSSQSEC
QVRAGTPAHESPQNNAFKCQETVRLQPRIDQRTAISPKDAFETRQDLNEEEAAQVHGVKD
PAPASTQSVLADGTDSADPSPVHKDGQNEADSAPEDLHSVGTSRLLYHITDGDNPLLSPR
CSIFSQSQRFNLDPESAPSPPSTQQFMMPRSSSRCSCGDGKEPQTITQLTKHIQSLKRKI
RKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPKGPPR
NLLCEQPTVPRENGKPEAAGPEPSSSGEETPDAALTCLKERREQLPPQEDSKVTKQDKNL
IKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGSQQPSLADPASHLPVGDHLTYSN
ETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDHLRETRADKKRLRKALREFEEQFF
KQTGRSPQKEDRIPMADEYYEYKHIKAKLRLLEVLISKQDVAKTI
Target Bioclass
Other
Family
FAM13 family
Uniprot ID
Q8NE31
Ensemble ID
ENST00000422313.6
HGNC ID
HGNC:19371

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.I155M .
DU145 SNV: p.D332Y .
HCC44 SNV: p.Q284K .
HDQP1 SNV: p.G473R .
MEWO SNV: p.R249K .
MOLT4 SNV: p.C277R .
NCIH2286 SNV: p.Q67R .
NCIH358 SNV: p.R102G .
SKMEL5 SNV: p.G280S .
SW948 SNV: p.T20A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TFBX
 Probe Info  		N.A.  LDD0027  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kinesin-like protein KIF2A (KIF2A) Kinesin family O00139
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-2 (MEOX2) . P50222
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 172 (CCDC172) CCDC172 family P0C7W6
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6
LRP chaperone MESD (MESD) MESD family Q14696
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Polyhomeotic-like protein 2 (PHC2) . Q8IXK0
Syntenin-2 (SDCBP2) . Q9H190

References

1 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255