Details of the Target

General Information of Target

Target ID LDTP09104
Target Name Sperm microtubule inner protein 6 (SPMIP6)
Gene Name SPMIP6
Gene ID 84688
Synonyms
C9orf24; CBE1; SMRP1; Sperm microtubule inner protein 6; Ciliated bronchial epithelial protein 1; Spermatid-specific manchette-related protein 1; Testis development protein NYD-SP22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFLFSRKTRTPISTYSDSYRAPTSIKEVYKDPPLCAWEANKFLTPGLTHTMERHVDPEAL
QKMAKCAVQDYTYRGSISGHPYLPEKYWLSQEEADKCSPNYLGSDWYNTWRMEPYNSSCC
NKYTTYLPRLPKEARMETAVRGMPLECPPRPERLNAYEREVMVNMLNSLSRNQQLPRITP
RCGCVDPLPGRLPFHGYESACSGRHYCLRGMDYYASGAPCTDRRLRPWCREQPTMCTSLR
APARNAVCCYNSPAVILPISEP
Target Bioclass
Other
Family
SMRP1 family
Subcellular location
Cytoplasm, cytoskeleton
Function May participate in intramanchette transport and midpiece formation of the sperm tail. May play a potential role in somatic cell proliferation.
Uniprot ID
Q8NCR6
Ensemble ID
ENST00000297623.7
HGNC ID
HGNC:19919

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.P151L .
CCK81 SNV: p.K65E .
SKNSH SNV: p.E231Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
JW-RF-010
 Probe Info  		N.A.  LDD0026  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Testis-specific serine/threonine-protein kinase 3 (TSSK3) CAMK Ser/Thr protein kinase family Q96PN8
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Chloride intracellular channel protein 3 (CLIC3) Chloride channel CLIC family O95833
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein prophet of Pit-1 (PROP1) Paired homeobox family O75360
B-cell lymphoma 6 protein (BCL6) . P41182
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 19-6 (KRTAP19-6) KRTAP type 19 family Q3LI70
Keratin-associated protein 9-3 (KRTAP9-3) KRTAP type 9 family Q9BYQ3
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
Pre-mRNA-splicing factor SPF27 (BCAS2) SPF27 family O75934
Tektin-4 (TEKT4) Tektin family Q8WW24
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
APOBEC1 complementation factor (A1CF) . Q9NQ94
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Calcium-binding protein 2 (CABP2) . Q9NPB3
Collagen alpha-1(VIII) chain (COL8A1) . P27658
Heat shock factor 2-binding protein (HSF2BP) . O75031
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
RNA-binding protein with multiple splicing (RBPMS) . Q93062

References

1 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255