Details of the Target
General Information of Target
| Target ID | LDTP09084 | |||||
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| Target Name | Neuropilin and tolloid-like protein 2 (NETO2) |
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| Gene Name | NETO2 | |||||
| Gene ID | 81831 | |||||
| Synonyms |
BTCL2; Neuropilin and tolloid-like protein 2; Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2 |
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| 3D Structure | ||||||
| Sequence |
MALERLCSVLKVLLITVLVVEGIAVAQKTQDGQNIGIKHIPATQCGIWVRTSNGGHFASP
NYPDSYPPNKECIYILEAAPRQRIELTFDEHYYIEPSFECRFDHLEVRDGPFGFSPLIDR YCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFE LSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVA VYDGSSSIENLKAKFCSTVANDVMLKTGIGVIRMWADEGSRLSRFRMLFTSFVEPPCTSS TFFCHSNMCINNSLVCNGVQNCAYPWDENHCKEKKKAGVFEQITKTHGTIIGITSGIVLV LLIISILVQVKQPRKKVMACKTAFNKTGFQEVFDPPHYELFSLRDKEISADLADLSEELD NYQKMRRSSTASRCIHDHHCGSQASSVKQSRTNLSSMELPFRNDFAQPQPMKTFNSTFKK SSYTFKQGHECPEQALEDRVMEEIPCEIYVRGREDSAQASISIDF |
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| Target Bioclass |
Transporter and channel
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| Subcellular location |
Membrane
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| Function |
Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
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Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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IPM Probe Info |
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N.A. | LDD2156 | [1] | |
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Phosphinate-6 Probe Info |
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N.A. | LDD0018 | [2] | |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 (FGFR3) | Tyr protein kinase family | P22607 | |||
Other
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Gelsolin (GSN) | Villin/gelsolin family | P06396 | |||
| Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) | . | Q7Z699 | |||
| Ubiquilin-1 (UBQLN1) | . | Q9UMX0 | |||
References