Details of the Target

General Information of Target

Target ID LDTP09068
Target Name POC1 centriolar protein homolog A (POC1A)
Gene Name POC1A
Gene ID 25886
Synonyms
WDR51A; POC1 centriolar protein homolog A; Pix2; Proteome of centriole protein 1A; WD repeat-containing protein 51A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGH
KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT
ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV
HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS
GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS
NFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESVQSQPQEPVSVPQTLT
STLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQQLIMQRATP
Target Bioclass
Other
Family
WD repeat POC1 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation.
Uniprot ID
Q8NBT0
Ensemble ID
ENST00000296484.7
HGNC ID
HGNC:24488

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
UACC257 SNV: p.V92G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C394(0.94)  LDD1508  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
NAIA_5
 Probe Info  		N.A.  LDD2225  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C394(0.94)  LDD1508  [1]
 LDCM0277  AC18 HEK-293T C394(1.04)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C394(0.99)  LDD1518  [1]
 LDCM0286  AC26 HEK-293T C394(0.95)  LDD1525  [1]
 LDCM0295  AC34 HEK-293T C394(0.93)  LDD1534  [1]
 LDCM0304  AC42 HEK-293T C394(0.92)  LDD1543  [1]
 LDCM0313  AC50 HEK-293T C394(1.03)  LDD1552  [1]
 LDCM0321  AC58 HEK-293T C394(0.98)  LDD1560  [1]
 LDCM0371  CL102 HEK-293T C394(0.99)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C394(0.90)  LDD1576  [1]
 LDCM0375  CL106 HEK-293T C394(0.90)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C394(1.00)  LDD1580  [1]
 LDCM0380  CL110 HEK-293T C394(0.90)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C394(0.88)  LDD1585  [1]
 LDCM0384  CL114 HEK-293T C394(0.96)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C394(0.99)  LDD1589  [1]
 LDCM0388  CL118 HEK-293T C394(0.98)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C394(0.98)  LDD1593  [1]
 LDCM0393  CL122 HEK-293T C394(1.03)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C394(0.91)  LDD1598  [1]
 LDCM0397  CL126 HEK-293T C394(1.01)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C394(0.93)  LDD1602  [1]
 LDCM0401  CL14 HEK-293T C394(0.96)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C394(0.93)  LDD1606  [1]
 LDCM0405  CL18 HEK-293T C394(1.20)  LDD1609  [1]
 LDCM0407  CL2 HEK-293T C394(0.98)  LDD1611  [1]
 LDCM0414  CL26 HEK-293T C394(0.84)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C394(1.09)  LDD1619  [1]
 LDCM0418  CL3 HEK-293T C394(0.89)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C394(1.11)  LDD1623  [1]
 LDCM0428  CL39 HEK-293T C394(1.06)  LDD1632  [1]
 LDCM0432  CL42 HEK-293T C394(1.15)  LDD1636  [1]
 LDCM0441  CL50 HEK-293T C394(1.11)  LDD1645  [1]
 LDCM0445  CL54 HEK-293T C394(1.08)  LDD1648  [1]
 LDCM0451  CL6 HEK-293T C394(1.04)  LDD1654  [1]
 LDCM0454  CL62 HEK-293T C394(0.93)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C394(1.13)  LDD1658  [1]
 LDCM0458  CL66 HEK-293T C394(1.00)  LDD1661  [1]
 LDCM0467  CL74 HEK-293T C394(0.96)  LDD1670  [1]
 LDCM0471  CL78 HEK-293T C394(1.20)  LDD1674  [1]
 LDCM0480  CL86 HEK-293T C394(1.03)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C394(1.06)  LDD1684  [1]
 LDCM0485  CL90 HEK-293T C394(0.96)  LDD1688  [1]
 LDCM0493  CL98 HEK-293T C394(0.99)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C394(0.88)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C394(0.94)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C394(1.03)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C394(0.99)  LDD1631  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) 2-oxoacid dehydrogenase family P36957
Serine/threonine-protein kinase Nek7 (NEK7) NEK Ser/Thr protein kinase family Q8TDX7
Ataxin-3 (ATXN3) . P54252
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calreticulin (CALR) Calreticulin family P27797
Huntingtin (HTT) Huntingtin family P42858
Cadherin-1 (CDH1) . P12830
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet endothelial cell adhesion molecule (PECAM1) . P16284

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264