Details of the Target
General Information of Target
| Target ID | LDTP09035 | |||||
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| Target Name | Histone-lysine N-methyltransferase SMYD1 (SMYD1) |
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| Gene Name | SMYD1 | |||||
| Gene ID | 150572 | |||||
| Synonyms |
Histone-lysine N-methyltransferase SMYD1; EC 2.1.1.354; SET and MYND domain-containing protein 1 |
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| 3D Structure | ||||||
| Sequence |
MTIGRMENVEVFTAEGKGRGLKATKEFWAADIIFAERAYSAVVFDSLVNFVCHTCFKRQE
KLHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIKRYGKVPNENIRLAARIMWRVEREGTG LTEGCLVSVDDLQNHVEHFGEEEQKDLRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCN GFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIELRALG KISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHCQKKLKDDLFLGVKDNPKPSQE VVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNIYMLRMLSIVSEV LSYLQAFEEASFYARRMVDGYMKLYHPNNAQLGMAVMRAGLTNWHAGNIEVGHGMICKAY AILLVTHGPSHPITKDLEAMRVQTEMELRMFRQNEFMYYKMREAALNNQPMQVMAEPSNE PSPALFHKKQ |
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| Target Bioclass |
Enzyme
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| Family |
Class V-like SAM-binding methyltransferase superfamily
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| Subcellular location |
Cytoplasm
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| Function |
Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C417(1.55) | LDD3401 | [1] | |
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m-APA Probe Info |
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N.A. | LDD2234 | [2] | |
Competitor(s) Related to This Target
References