Details of the Target
General Information of Target
| Target ID | LDTP08912 | |||||
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| Target Name | BTB/POZ domain-containing protein KCTD17 (KCTD17) |
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| Gene Name | KCTD17 | |||||
| Gene ID | 79734 | |||||
| Synonyms |
BTB/POZ domain-containing protein KCTD17 |
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| 3D Structure | ||||||
| Sequence |
MRMEAGEAAPPAGAGGRAAGGWGKWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQ
SDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEEAEFYNIGPLIRIIKDR MEEKDYTVTQVPPKHVYRVLQCQEEELTQMVSTMSDGWRFEQLVNIGSSYNYGSEDQAEF LCVVSKELHSTPNGLSSESSRKTKSTEEQLEEQQQQEEEVEEVEVEQVQVEADAQEKAQS SQDPANLFSLPPLPPPPLPAGGSRPHPLRPEAELAVRASPRPLARPQSCHPCCYKPEAPG CEAPDHLQGLGVPI |
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| Target Bioclass |
Other
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| Subcellular location |
Cytoplasm
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| Function |
Substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediates the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation. Thereby, positively regulates ciliogenesis, playing a crucial role in the initial steps of axoneme extension. May also play a role in endoplasmic reticulum calcium ion homeostasis.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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DBIA Probe Info |
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C61(1.06) | LDD3339 | [1] | |
Competitor(s) Related to This Target
References