Details of the Target
General Information of Target
| Target ID | LDTP08882 | |||||
|---|---|---|---|---|---|---|
| Target Name | Fibrinogen C domain-containing protein 1 (FIBCD1) | |||||
| Gene Name | FIBCD1 | |||||
| Gene ID | 84929 | |||||
| Synonyms |
Fibrinogen C domain-containing protein 1 |
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| 3D Structure | ||||||
| Sequence |
MVNDRWKTMGGAAQLEDRPRDKPQRPSCGYVLCTVLLALAVLLAVAVTGAVLFLNHAHAP
GTAPPPVVSTGAASANSALVTVERADSSHLSILIDPRCPDLTDSFARLESAQASVLQALT EHQAQPRLVGDQEQELLDTLADQLPRLLARASELQTECMGLRKGHGTLGQGLSALQSEQG RLIQLLSESQGHMAHLVNSVSDILDALQRDRGLGRPRNKADLQRAPARGTRPRGCATGSR PRDCLDVLLSGQQDDGVYSVFPTHYPAGFQVYCDMRTDGGGWTVFQRREDGSVNFFRGWD AYRDGFGRLTGEHWLGLKRIHALTTQAAYELHVDLEDFENGTAYARYGSFGVGLFSVDPE EDGYPLTVADYSGTAGDSLLKHSGMRFTTKDRDSDHSENNCAAFYRGAWWYRNCHTSNLN GQYLRGAHASYADGVEWSSWTGWQYSLKFSEMKIRPVREDR |
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| Target Bioclass |
Other
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| Subcellular location |
Membrane
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| Function |
Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| DOTC24510 | SNV: p.N418K | DBIA Probe Info | |||
| HT115 | SNV: p.A402V | . | |||
| IM95 | SNV: p.G426S | . | |||
| MEWO | SNV: p.F261Y | . | |||
| NCIH1993 | SNV: p.G279D | . | |||
| PC9 | SNV: p.Q252H | . | |||
| SHP77 | SNV: p.G311W | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C77(3.98) | LDD3458 | [1] | |
Competitor(s) Related to This Target