Details of the Target

General Information of Target

Target ID LDTP08880
Target Name EF-hand calcium-binding domain-containing protein 4A (CRACR2B)
Gene Name CRACR2B
Gene ID 283229
Synonyms
EFCAB4A; EF-hand calcium-binding domain-containing protein 4A; Calcium release-activated calcium channel regulator 2B; CRAC channel regulator 2B; Calcium release-activated channel regulator 2B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASPGKPGADEAQEEEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSD
LPLTPEQLEAVFESLDRAHTGFLTAREFCLGLGMFVGVASAQGANPCRTPEETFESGGLD
VQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLI
RASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRS
RLELELQSREQDLERAGLRQRELEQQLHAQAAEHLEAQAQNSQLWRAHEALRTQLEGAQE
QIRRLESEARGRQEQTQRDVVAVSRNMQKEKVSLLRQLELLRELNTRLRDDRDACEARRA
GSSCRKALTTARLPGPTCCCCCCWARPPRRGSGHLPSAR
Target Bioclass
Other
Family
EFCAB4 family
Function Plays a role in store-operated Ca(2+) entry (SOCE).
Uniprot ID
Q8N4Y2
Ensemble ID
ENST00000450448.5
HGNC ID
HGNC:28703

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL27 SNV: p.E112Ter .
LS180 SNV: p.G118R .
MFE319 SNV: p.A371T .
MOLT4 SNV: p.G81S .
MSTO211H SNV: p.G97A .
NCIH1155 SNV: p.R249C .
NUGC3 Deletion: p.A298RfsTer47 .
RKO Deletion: p.G22AfsTer136
SNV: p.A298V		 .
T98G Insertion: p.L39SfsTer4 .
TOV21G SNV: p.D353Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C185(2.90)  LDD3314  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AU565 C185(1.68)  LDD2265  [1]
 LDCM0023  KB03 AU565 C185(3.29)  LDD2682  [1]
 LDCM0024  KB05 IGR37 C185(2.90)  LDD3314  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840