Details of the Target

General Information of Target

Target ID LDTP08868
Target Name Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (PIP4P2)
Gene Name PIP4P2
Gene ID 55529
Synonyms
TMEM55A; Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Type 2 PtdIns-4,5-P2 4-Ptase; EC 3.1.3.78; PtdIns-4,5-P2 4-Ptase II; Transmembrane protein 55A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAADGVDERSPLLSASHSGNVTPTAPPYLQESSPRAELPPPYTAIASPDASGIPVINCRV
CQSLINLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPN
CRRIINLGPVMLISEEQPAQPALPIQPEGTRVVCGHCGNTFLWMELRFNTLAKCPHCKKI
SSVGSALPRRRCCAYITIGMICIFIGVGLTVGTPDFARRFRATYVSWAIAYLLGLICLIR
ACYWGAIRVSYPEHSFA
Target Bioclass
Enzyme
Subcellular location
Late endosome membrane
Function
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation.
Uniprot ID
Q8N4L2
Ensemble ID
ENST00000285419.8
HGNC ID
HGNC:25452

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.96  LDD0402  [1]
DBIA
 Probe Info  		C61(1.35)  LDD3312  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0372  CL103 HEK-293T C81(0.85)  LDD1576  [4]
 LDCM0376  CL107 HEK-293T C81(0.79)  LDD1580  [4]
 LDCM0381  CL111 HEK-293T C81(0.93)  LDD1585  [4]
 LDCM0385  CL115 HEK-293T C81(0.91)  LDD1589  [4]
 LDCM0389  CL119 HEK-293T C81(0.85)  LDD1593  [4]
 LDCM0394  CL123 HEK-293T C81(0.76)  LDD1598  [4]
 LDCM0398  CL127 HEK-293T C81(0.91)  LDD1602  [4]
 LDCM0402  CL15 HEK-293T C81(0.74)  LDD1606  [4]
 LDCM0415  CL27 HEK-293T C81(0.91)  LDD1619  [4]
 LDCM0418  CL3 HEK-293T C81(0.81)  LDD1622  [4]
 LDCM0428  CL39 HEK-293T C81(1.01)  LDD1632  [4]
 LDCM0455  CL63 HEK-293T C81(0.96)  LDD1658  [4]
 LDCM0481  CL87 HEK-293T C81(1.05)  LDD1684  [4]
 LDCM0494  CL99 HEK-293T C81(0.86)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C81(0.92)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C81(1.03)  LDD1671  [4]
 LDCM0022  KB02 HEK-293T C61(0.98)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C61(1.12)  LDD1497  [4]
 LDCM0024  KB05 HMCB C61(1.35)  LDD3312  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Protrudin (ZFYVE27) . Q5T4F4
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor (TNF) Tumor necrosis factor family P01375

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402