Details of the Target

General Information of Target

Target ID LDTP08846
Target Name Epidermal retinol dehydrogenase 2 (SDR16C5)
Gene Name SDR16C5
Gene ID 195814
Synonyms
RDHE2; Epidermal retinol dehydrogenase 2; EPHD-2; RDH-E2; EC 1.1.1.105; Retinal short-chain dehydrogenase reductase 2; retSDR2; Short-chain dehydrogenase/reductase family 16C member 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSFNLQSSKKLFIFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQF
ARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVS
ILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAG
LSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCPS
LLPILEPKYAVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPLKTGLLIADYLGILHAMD
GFVDQKKKL
Target Bioclass
Enzyme
Family
Short-chain dehydrogenases/reductases (SDR) family
Subcellular location
Endoplasmic reticulum membrane
Function
Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH.
Uniprot ID
Q8N3Y7
Ensemble ID
ENST00000303749.8
HGNC ID
HGNC:30311

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.F14V DBIA    Probe Info 
IGR1 SNV: p.S18L .
JHH7 SNV: p.N4H .
K562 SNV: p.T96P .
SH4 SNV: p.P162L .
SNU1 SNV: p.A25V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C81(1.65); C222(1.04)  LDD3312  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A-549 C81(1.34); C222(1.06)  LDD2260  [1]
 LDCM0023  KB03 A-549 C81(1.44); C222(1.02)  LDD2677  [1]
 LDCM0024  KB05 HMCB C81(1.65); C222(1.04)  LDD3312  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Glutamate decarboxylase 2 (GAD2) Group II decarboxylase family Q05329
Sentrin-specific protease 2 (SENP2) Peptidase C48 family Q9HC62
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sorting nexin-1 (SNX1) Sorting nexin family Q13596
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock transcription factor, X-linked (HSFX1; HSFX2) HSF family Q9UBD0
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
FUN14 domain-containing protein 2 (FUNDC2) FUN14 family Q9BWH2
Synaptotagmin-16 (SYT16) Synaptotagmin family Q17RD7
Alpha-tocopherol transfer protein (TTPA) . P49638

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840