Details of the Target

General Information of Target

Target ID LDTP08805
Target Name Protein odd-skipped-related 2 (OSR2)
Gene Name OSR2
Gene ID 116039
Synonyms
Protein odd-skipped-related 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSKALPAPIPLHPSLQLTNYSFLQAVNTFPATVDHLQGLYGLSAVQTMHMNHWTLGYPN
VHEITRSTITEMAAAQGLVDARFPFPALPFTTHLFHPKQGAIAHVLPALHKDRPRFDFAN
LAVAATQEDPPKMGDLSKLSPGLGSPISGLSKLTPDRKPSRGRLPSKTKKEFICKFCGRH
FTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDHRYIHSKEKPFKCQECGKGFCQS
RTLAVHKTLHMQESPHKCPTCGRTFNQRSNLKTHLLTHTDIKPYSCEQCGKVFRRNCDLR
RHSLTHTPRQDF
Target Bioclass
Transcription factor
Family
Odd C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in the development of the mandibular molar tooth germ at the bud stage.
Uniprot ID
Q8N2R0
Ensemble ID
ENST00000297565.9
HGNC ID
HGNC:15830

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.H278D .
CALU6 SNV: p.D280E .
HCC44 SNV: p.S285R .
HCT15 SNV: p.T182I; p.T195M .
HEC1B SNV: p.P165S .
IPC298 SNV: p.N28S .
MELJUSO SNV: p.V34G .
SW620 Substitution: p.Q76G .
TKKK SNV: p.T126K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0230  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0230  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome subunit alpha type-3 (PSMA3) Peptidase T1A family P25788
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 6-1 (KRTAP6-1) KRTAP type 6 family Q3LI64

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.