Details of the Target

General Information of Target

Target ID LDTP08781
Target Name Carbonic anhydrase 13 (CA13)
Gene Name CA13
Gene ID 377677
Synonyms
Carbonic anhydrase 13; EC 4.2.1.1; Carbonate dehydratase XIII; Carbonic anhydrase XIII; CA-XIII
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRLSWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKII
SNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELH
VVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNF
DLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAA
FLVSNHRPPQPLKGRKVRASFH
Target Bioclass
Enzyme
Family
Alpha-carbonic anhydrase family
Function Reversible hydration of carbon dioxide.
Uniprot ID
Q8N1Q1
Ensemble ID
ENST00000321764.4
HGNC ID
HGNC:14914
ChEMBL ID
CHEMBL3912

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0162  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CREB-regulated transcription coactivator 3 (CRTC3) TORC family Q6UUV7

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Benzthiazide Small molecular drug DB00562
Cyclothiazide Small molecular drug DB00606
Zonisamide Small molecular drug DB00909
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
N-(4-chlorobenzyl)-n-methylbenzene-14-disulfonamide . DB07115

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060